期刊
CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION
卷 57, 期 6, 页码 1256-1269出版社
TAYLOR & FRANCIS INC
DOI: 10.1080/10408398.2014.984802
关键词
Phellinus sensu lato; polysaccharides; structure; antitumor; mechanism
资金
- Natural Science Foundation of Jiangsu Province [BK20140542]
- China Postdoctoral Science Foundation [2013M531292]
- Priority Academic Program Development (PAPD) of Jiangsu Higher Education Institutions
- Science and Technology Support Plan (Industry) of Zhenjiang [GY2013006]
Edible and medicinal fungi (mushrooms) are widely applied to functional foods and nutraceutical products because of their proven nutritive and medicinal properties. Phellinus sensu lato is a well-known medicinal mushroom that has long been used in preventing ailments, including gastroenteric dysfunction, diarrhea, hemorrhage, and cancers, in oriental countries, particularly in China, Japan, and Korea. Polysaccharides represent a major class of bioactive molecules in Phellinus s. l., which have notable antitumor, immunomodulatory, and medicinal properties. Polysaccharides that were isolated from fruiting bodies, cultured mycelia, and filtrates of Phellinus s. l. have not only activated different immune responses of the host organism but have also directly suppressed tumor growth and metastasis. Studies suggest that polysaccharides from Phellinus s. l. are promising alternative anticancer agents or synergizers for existing antitumor drugs. This review summarizes the recent development of polysaccharides from Phellinus s. l., including polysaccharide production, extraction and isolation methods, chemical structure, antitumor activities, and mechanisms of action.
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