期刊
CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION
卷 57, 期 9, 页码 1799-1806出版社
TAYLOR & FRANCIS INC
DOI: 10.1080/10408398.2015.1006768
关键词
Rosmarinic acid; therapeutic; nutraceutical; cytoprotective properties; pharmacokinetic profile; in vivo models
资金
- FCT (Fundacao para a Ciencia e Tecnologia, Portugal) [PTDC/AGR-ALI/117808/2010, PEst-OE/EQB/LA0016/2013]
- FCT [SFRH/BPD/71391/2010, SFRH/BD/109017/2015, UID/NEU/04539/2013]
- FEDER-COMPETE [FCOMP-01-0124-FEDER-028417, POCI-01-0145-FEDER-007440]
- Fundação para a Ciência e a Tecnologia [UID/NEU/04539/2013, PEst-OE/EQB/LA0016/2013, PTDC/AGR-ALI/117808/2010, SFRH/BD/109017/2015] Funding Source: FCT
Rosmarinic acid (RA) is a natural polyphenolic antioxidant derived from many common herbal plants. This compound displays several important biological properties, including anti-inflammatory, antiviral, antibacterial, antidepressant, anticarcionogenic, and chemopreventive properties. The importance of its activities and its possible application in processed foods as a natural antioxidant has reached a new interest levels in recent years. The health effects of this polyphenol depend greatly on both its intakes and bioavailability. This review focuses on the importance of RA as a dietary supplement, and summarizes its pharmacokinetics and metabolism, including the factors that limit its oral bioavailability which leads to a lower therapeutic action. Further experimental investigations are needed to optimize and enhance the oral bioavailability of this natural compound which consequently will help increasing therapeutic efficacy of RA in vivo.
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