期刊
BIOMATERIALS
卷 260, 期 -, 页码 -出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.biomaterials.2020.120339
关键词
Black phosphorus nanosheets; Drug delivery; Lactoferrin; Blood-brain barrier; Brain targeting
资金
- Guangdong Basic and Applied Basic Research Foundation [2019B1515120043]
- Guangdong Provincial Natural Science Foundation of China [2018A030310623]
- Guangdong Provincial Medical Scientific Research Foundation of China [A2019027]
- Research Fund of University of Macau [MYRG2019-00121-ICMS, MYRG2018-00207ICMS]
- Instrumental Analysis Center of Shenzhen University (Xili Campus)
The treatment of Parkinson's disease (PD) is hampered by the blood-brain barrier (BBB). As such, there is an urgent need for the development of a novel nanoplatform capable of penetrating the BBB in order to effectively treat PD. In the present study, we utilized black phosphorus nanosheets (BP) containing the brain-targeting ligand lactoferrin (Lf) and loaded with Paeoniflorin (Pae) to obtain Lf-BP-Pae. Through an effective photothermal effect, these Lf-BP-Pae particles were capable of traversing the BBB and effectively treating PD in a targeted manner. Importantly, this BP-based nanoplatform was capable of achieving satisfactory biocompatibility and biosafety with excellent anti-Parkinsonian efficacy, making it ideal for clinical applications.
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