期刊
CRITICAL REVIEWS IN BIOTECHNOLOGY
卷 36, 期 6, 页码 1036-1049出版社
TAYLOR & FRANCIS LTD
DOI: 10.3109/07388551.2015.1083942
关键词
Biotransformation; classification; ginsenosidase; ginsenoside hydrolysis; glycosidase
资金
- Basic Research Lab program [2010-0019306]
- National Research Foundation
- Ministry of Science, ICT and Future Planning, Republic of Korea
Ginsenosides are the main compounds with pharmacological activities in ginseng. Deglycosylated ginsenosides, which are more pharmacologically active than glycosylated ginsenosides, can be produced by the specific or nonspecific hydrolysis of the sugar moieties in glycosylated ginsenosides using glycosidases. The enzymes that hydrolyze specifically ginsenosides with different types can be classified according to the enzymatic activity on the positions, inner and outer residues and types of sugar moieties in ginsenosides. Glycosylated ginsenosides are also hydrolyzed to deglycosylated ginsenosides with different hydrolytic pathways by cell conversion or fermentation. The biochemical properties of glycosidases involved in ginsenoside hydrolysis - ginsenosidases - were newly arranged and reviewed in accordance with different types. The combination of different-type ginsenosidases is suggested herein as an efficient tool to produce industrially important ginsenosides.
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