期刊
AGING CELL
卷 14, 期 3, 页码 491-495出版社
WILEY-BLACKWELL
DOI: 10.1111/acel.12325
关键词
biomarker of aging; DNA methylation; Down syndrome; epigenetics
资金
- National Institutes of Health [NIA/NIH 5R01AG042511-02]
- Univ of California Multi-Campus Research grant (MRPI)
- European Union [259679]
- CARISBO foundation
- Italian Ministry of Health [35]
- [P50 AG16570]
Down Syndrome (DS) entails an increased risk of many chronic diseases that are typically associated with older age. The clinical manifestations of accelerated aging suggest that trisomy 21 increases the biological age of tissues, but molecular evidence for this hypothesis has been sparse. Here, we utilize a quantitative molecular marker of aging (known as the epigenetic clock) to demonstrate that trisomy 21 significantly increases the age of blood and brain tissue (on average by 6.6years, P=7.0x10(-14)).
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