期刊
JOURNAL OF ALZHEIMERS DISEASE REPORTS
卷 4, 期 1, 页码 123-140出版社
IOS PRESS
DOI: 10.3233/ADR-200177
关键词
Alzheimer's disease; amyloid; amyloid-beta protein precursor; endocytosis; endosomes; protein transport
资金
- Australian Government Research Training Program Scholarship
- National Health and Medical Research Council (NHMRC) [APP1061006]
- NHMRC [APP1061006, APP1045507]
Sortilin-related receptor 1 (SORL1) encodes a large, multi-domain containing, membrane-bound receptor involved in endosomal sorting of proteins between the trans-Golgi network, endosomes and the plasma membrane. It is genetically associated with Alzheimer's disease (AD), the most common form of dementia. SORL1 is a unique gene in AD, as it appears to show strong associations with the common, late-onset, sporadic form of AD and the rare, early-onset familial form of AD. Here, we review the genetics of SORL1 in AD and discuss potential roles it could play in AD pathogenesis.
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