期刊
HEALTH EXPECTATIONS
卷 21, 期 1, 页码 75-81出版社
WILEY
DOI: 10.1111/hex.12587
关键词
antimicrobial drug development; microbiology; patient and public involvement
类别
资金
- Innovative Medicines Initiative Joint Undertaking from the European Union Seventh Framework Programme (FP7) [115523, 115620, 115737]
- EFPIA companies
BackgroundPatient and public involvement (PPI) is increasingly recognized as bringing a range of benefits to clinical and health services research. Recent systematic reviews have identified and synthesized many benefits (eg higher recruitment rates) and some costs (eg extra time need). Much of the literature focuses on PPI in long-term conditions rather than more acute health care in which the majority of microbiological research is undertaken. ObjectivesThe aim was to identify the extent, quality and impact of PPI in antimicrobial drug development research. Objectives were to identify any relevant reporting of PPI in antimicrobial research; appraise the quality of reporting on PPI using recognized PPI reporting and critical appraisal tools; and extract and synthesize data on the impact of PPI. Search strategyA systematic review was undertaken with a search strategy based on four word groups (PPI, patients, antimicrobial drug development and outcomes). Eight online databases were searched. Inclusion criteriaEnglish language publication, publication between 1996 and 2016 and studies describing PPI in antimicrobial drug development research. Main resultsNo studies were found through online searching that met the search strategy and inclusion criteria. One relevant protocol paper with a brief mention of PPI was identified through expert recommendation. Commentary papers recommending PPI were identified through website searching and expert opinion. Discussion and conclusionsDespite strong policy guidance encouraging PPI at the international and national levels, and anecdotal accounts of PPI taking place, evidence for the extent, quality and impact of PPI in antimicrobial drug development research has not yet appeared in the peer-reviewed literature.
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