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Aggregated α-synuclein activates microglia:: a process leading to disease progression in Parkinson's disease
W Zhang et al.
FASEB JOURNAL (2005)
Treatment of Parkinson disease with diet-induced hyperketonemia: A feasibility study
TB VanItallie et al.
NEUROLOGY (2005)
Microglial activation and dopamine terminal loss in early Parkinson's disease
Y Ouchi et al.
ANNALS OF NEUROLOGY (2005)
Microglial inflammation in the parkinsonian substantia nigra: relationship to alpha-synuclein deposition
Emilie Croisier et al.
JOURNAL OF NEUROINFLAMMATION (2005)
Mitochondrial microheteroplasmy and a theory of aging and age-related disease
RM Smigrodzki et al.
REJUVENATION RESEARCH (2005)
Neuromelanin in human dopamine neurons: Comparison with peripheral melanins and relevance to Parkinson's disease
H Fedorow et al.
PROGRESS IN NEUROBIOLOGY (2005)
Mitochondrial dysfunction and oxidative damage in parkin-deficient mice
JJ Palacino et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2004)
Aging of the nigrostriatal system in the squirrel monkey
AL McCormack et al.
JOURNAL OF COMPARATIVE NEUROLOGY (2004)
Clinical phenotype of families with longevity
G Atzmon et al.
JOURNAL OF THE AMERICAN GERIATRICS SOCIETY (2004)
Interleukin-6 in the aging brain
JP Godbout et al.
JOURNAL OF NEUROIMMUNOLOGY (2004)
PINK1 mutations are associated with sporadic early-onset parkinsonism
EM Valente et al.
ANNALS OF NEUROLOGY (2004)
Response of the GABAergic and dopaminergic mesostriatal projections to the lesion of the contralateral dopaminergic mesostriatal pathway in the rat
T González-Hernández et al.
MOVEMENT DISORDERS (2004)
Impaired degradation of mutant α-synuclein by chaperone-mediated autophagy
AM Cuervo et al.
SCIENCE (2004)
Stabilization of α-synuclein protein with aging and familial Parkinson's disease-linked A53T mutation
WX Li et al.
JOURNAL OF NEUROSCIENCE (2004)
Molecular pathways to neurodegeneration
E Bossy-Wetzel et al.
NATURE MEDICINE (2004)
Dopamine depletion impairs precursor cell proliferation in Parkinson disease
GU Höglinger et al.
NATURE NEUROSCIENCE (2004)
A neural signaling triumvirate that influences ageing and age-related disease: insulin/IGF-1, BDNF and serotonin
MP Mattson et al.
AGEING RESEARCH REVIEWS (2004)
Evidence of active microglia in substantia nigra pars compacta of parkinsonian monkeys 1 year after MPTP exposure
C Barcia et al.
GLIA (2004)
Calcium, ATP, and ROS: a mitochondrial love-hate triangle
PS Brookes et al.
AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY (2004)
The role of oxidative damage and stress in aging
A Bokov et al.
MECHANISMS OF AGEING AND DEVELOPMENT (2004)
Hereditary early-onset Parkinson's disease caused by mutations in PINK1
EM Valente et al.
SCIENCE (2004)
Histological changes of the dopaminergic nigrostriatal system in aging
AK Stark et al.
CELL AND TISSUE RESEARCH (2004)
Mitochondrial complex I and IV activities in leukocytes from patients with parkin mutations
M Müftüoglu et al.
MOVEMENT DISORDERS (2004)
Screening for DJ-1 mutations in early onset autosomal recessive parkinsonism
P Ibáñez et al.
NEUROLOGY (2003)
Molecular pathways of neurodegeneration in Parkinson's disease
TM Dawson et al.
SCIENCE (2003)
DJ-1 (PARK7), a novel gene for autosomal recessive, early onset parkinsonism
V Bonifati et al.
NEUROLOGICAL SCIENCES (2003)
Prenatal exposure to the bacteriotoxin lipopolysaccharide leads to long-term losses of dopamine neurons in offspring: A potential, new model of Parkinson's disease
PM Carvey et al.
FRONTIERS IN BIOSCIENCE-LANDMARK (2003)
Ubiquitin carboxy-terminal hydrolase L1 binds to and stabilizes monoubiquitin in neuron
H Osaka et al.
HUMAN MOLECULAR GENETICS (2003)
α-synuclein is degraded by both autophagy and the proteasome
JL Webb et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2003)
Staging of brain pathology related to sporadic Parkinson's disease
H Braak et al.
NEUROBIOLOGY OF AGING (2003)
Relation of aging with oxidative protein damage parameters in the rat skeletal muscle
U Çakatay et al.
CLINICAL BIOCHEMISTRY (2003)
Gastrointestinal dysfunction in Parkinson's disease
RF Pfeiffer
LANCET NEUROLOGY (2003)
Mutations in the DJ-1 gene associated with autosomal recessive early-onset parkinsonism
V Bonifati et al.
SCIENCE (2003)
Oxidative stress in Parkinson's disease
P Jenner
ANNALS OF NEUROLOGY (2003)
Autoimmune encephalomyelitis and uveitis induced by T cell immunity to self beta-synuclein
F Mor et al.
JOURNAL OF IMMUNOLOGY (2003)
Marked disparity between age-related changes in dopamine and other presynaptic dopaminergic markers in human striatum
JW Haycock et al.
JOURNAL OF NEUROCHEMISTRY (2003)
Age-related alterations in the protein expression profile of C57BL/6J mouse pituitaries
G Marzban et al.
EXPERIMENTAL GERONTOLOGY (2002)
Microglia as neuroprotective, immunocompetent cells of the CNS
WJ Streit
GLIA (2002)
Rate of generation of oxidative stress-related damage and animal longevity
G Barja
FREE RADICAL BIOLOGY AND MEDICINE (2002)
Environmental factors in Parkinson's disease
DA Di Monte et al.
NEUROTOXICOLOGY (2002)
Ageing of substantia nigra in humans: cell loss may be compensated by hypertrophy
CR Cabello et al.
NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY (2002)
Glutathione release from cultured brain cells: Multidrug resistance protein 1 mediates the release of GSH from rat astroglial cells
J Hirrlinger et al.
JOURNAL OF NEUROSCIENCE RESEARCH (2002)
Endogenous oxidative stress: relationship to aging, longevity and caloric restriction
G Barja
AGEING RESEARCH REVIEWS (2002)
Genetics of Parkinson's disease and biochemical studies of implicated gene products
PT Lansbury et al.
CURRENT OPINION IN GENETICS & DEVELOPMENT (2002)
Ageing muscle:: clonal expansions of mitochondrial DNA point mutations and deletions cause focal impairment of mitochondrial function
G Fayet et al.
NEUROMUSCULAR DISORDERS (2002)
Mitochondrial involvement in Parkinson's disease
M Orth et al.
NEUROCHEMISTRY INTERNATIONAL (2002)
Telomere lengths are characteristic in each human individual
K Takubo et al.
EXPERIMENTAL GERONTOLOGY (2002)
'Senescence-associated' β-galactosidase activity in the upper gastrointestinal tract
JJ Going et al.
JOURNAL OF PATHOLOGY (2002)
Increase in dopamine turnover occurs early in Parkinson's disease:: Evidence from a new modeling approach to PET 18F-fluorodopa data
V Sossi et al.
JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM (2002)
The herbicide paraquat causes up-regulation and aggregation of α-synuclein in mice -: Paraquat and α-synuclein
AB Manning-Bog et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2002)
Changes in somatodendritic but not terminal dopamine regulation in aged rhesus monkeys
GA Gerhardt et al.
JOURNAL OF NEUROCHEMISTRY (2002)
In utero bacterial endotoxin exposure causes loss of tyrosine hydroxylase neurons in the postnatal rat midbrain
ZD Ling et al.
MOVEMENT DISORDERS (2002)
Motor behavioural changes after intracerebroventricular injection of 6-hydroxydopamine in the rat:: an animal model of Parkinson's disease
MR Díaz et al.
BEHAVIOURAL BRAIN RESEARCH (2001)
Dopamine cell degeneration induced by intraventricular administration of 6-hydroxydopamine in the rat:: Similarities with cell loss in Parkinson's disease
M Rodríguez et al.
EXPERIMENTAL NEUROLOGY (2001)
Colocalization of tyrosine hydroxylase and GAD65 mRNA in mesostriatal neurons
T Gonzalez-Hernandez et al.
EUROPEAN JOURNAL OF NEUROSCIENCE (2001)
Chronic systemic pesticide exposure reproduces features of Parkinson's disease
R Betarbet et al.
NATURE NEUROSCIENCE (2000)
Inflammatory regulators in Parkinson's disease: iNOS, lipocortin-1, and cyclooxygenases-1 and-2
C Knott et al.
MOLECULAR AND CELLULAR NEUROSCIENCE (2000)
Oxidative damage linked to neurodegeneration by selective α-synuclein nitration in synucleinopathy lesions
BI Giasson et al.
SCIENCE (2000)
The role of the locus coeruleus in the development of Parkinson's disease
M Gesi et al.
NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS (2000)
Age-related changes of neuronal counts in the human pedunculopontine nucleus
G Ransmayr et al.
NEUROSCIENCE LETTERS (2000)
Loss of thalamic intralaminar nuclei in progressive supranuclear palsy and Parkinson's disease: clinical and therapeutic implications
JM Henderson et al.
BRAIN (2000)
Association between early-onset Parkinson's disease and mutations in the parkin gene
CB Lücking et al.
NEW ENGLAND JOURNAL OF MEDICINE (2000)
Mice lacking alpha-synuclein display functional deficits in the nigrostriatal dopamine system
A Abeliovich et al.
NEURON (2000)
NACP/alpha-synuclein-positive filamentous inclusions in astrocytes and oligodendrocytes of Parkinson's disease brains
K Wakabayashi et al.
ACTA NEUROPATHOLOGICA (2000)
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