期刊
GUT AND LIVER
卷 11, 期 1, 页码 38-46出版社
EDITORIAL OFFICE GUT & LIVER
DOI: 10.5009/gnl15535
关键词
Colon cancer; Colorectal cancer; CpG island methylator henotype; Microsatellite instability; Serrated neoplasia
资金
- Basic Science Research Program through the National Research Foundation (NRF) - Korean Ministry of Education [2013R1A1A2059080]
- NRF - Korean Ministry of Science, ICT and Future planning [2011-0030049]
- Priority Research Centers Program of the NRF [2009-0093820]
- Korea Health Technology R&D Project of the Korea Health Industry Development Institute - Korean Ministry of Health and Welfare [HI14C1277]
The concept of a CpG island methylator phenotype (CIMP) was first introduced by Toyota and Issa to describe a subset of colorectal cancers (CRCs) with concurrent hypermethylation of multiple CpG island loch The concept of CIMP as a molecular carcinogenesis mechanism was consolidated by the identification of the serrated neoplasia pathway, in which CIMP participates in the initiation and progression of serrated adenomas. Distinct clinicopathological and molecular features of CIMP-high (CIMP-H) CRCs have been characterized, including proAmal colon location, older age of onset, female preponderance, and frequent associations of high-level microsatellite instability and BRAF mutations. CIMP-H CRCs arise in sessile or traditional serrated adenomas and thus tend to display the morphological characteristics of serrated adenomas, including epithelial serration, vesicular nuclei, and abundant cytoplasm. Both the frequent association of CIMP and poor prognosis and different responses of CRCs to adjuvant therapy depending on CIMP status indicate clinical implications. In this review, we present an overview of the literature documenting the relevant findings of CIMP-H CRCs and their relationships with the serrated neoplasia pathway.
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