期刊
GUT
卷 66, 期 9, 页码 1709-1717出版社
BMJ PUBLISHING GROUP
DOI: 10.1136/gutjnl-2017-313872
关键词
-
资金
- Science Foundation Ireland [APC/SFI/12/RC/2273]
- Abvie
- Alimentary Health
- Cremo
- Danone
- Janssen
- Friesland Campina
- General Mills
- Kerry
- MeadJohnson
- Nutricia
- 4D Pharma
- Second Genome
- Sigmoid Pharma
Advances in microbiome science cast light on traditional concepts on nutritional science, and are poised for clinical translation. Epidemiologic observations which linked lifestyle factors to risk of disease are being reinterpreted with mechanistic insight based on improved understanding of the microbiota. Examples include the role of dietary fibre in disease prevention, the deleterious effects of highly restricted diets, and the contribution of the microbiota to over-and undernutrition. While the microbiota transduces nutrient signals for the host, food and habitual diet shape the composition of the gut microbiota at every stage of life. The composition and diversity of food intake determines which microbes will colonise, flourish, persist, or become extinct. Disruption of the developing microbiota in infancy contributes to the risk of immune and metabolic disease in later life, whereas loss of microbes in the elderly due to monotonous diets has been linked with unhealthy ageing and frailty. This should influence modern dietary advice regarding prevention and management of chronic non-communicable inflammatory and metabolic disorders, and will inform the design of infant and future food formula. The microbiota profile is also emerging as a biomarker to predict responsiveness to dietary interventions and promises to make personalised nutrition a reality.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据