期刊
GREEN CHEMISTRY
卷 19, 期 24, 页码 5761-5766出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/c7gc02844j
关键词
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资金
- National Natural Science Foundation of China [21562005, 21602037, 21462008]
- Natural Science Foundation of Guangxi [2015GXNSFCA139001, 2016GXNSFFA380005]
- State Key Laboratory for Chemistry and Molecular Engineering of Medicinal Resources, Ministry of Science and Technology of China [CMEMR2015-A05]
- Ministry of Education of China [IRT_16R15]
- Overseas 100 Talents Program of Guangxi Higher Education
A variety of 2,3-quaternary fused indolines could be prepared in good yields with high diastereoselectivity from alkynyl tethered oximes and diaryliodonium salts under mild metal-free conditions. The reaction initially goes through a selective N-arylation to provide alkynyl tethered nitrones and regioselectively undergoes an intramolecular (3 + 2) cycloaddition followed by a [3,3]-sigmatropic rearrangement to afford 2,3-quaternary fused indolines in a one-pot fashion. The method features easily available cheap materials, multiple bond formation, gram scalable preparation and diversity of fused indoline scaffolds.
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