期刊
GREEN CHEMISTRY
卷 19, 期 22, 页码 5396-5402出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/c7gc02174g
关键词
-
资金
- National Natural Science Foundation of China [21373003, 21676076]
- Natural Science Foundation of Hunan Province [2016JJ3034]
- Hunan Youth Talent [2016RS3023]
- HNU
A highly efficient way for the direct (trans) esterification of acyl acids (esters) and alcohols in a strict 1 : 1 ratio using a zirconocene complex (1, 1 mol%), a strong Lewis acid of good water tolerance, as a catalyst under solvent-free conditions has been developed. A wide range of acid and alcohol (esters) substrates undergo (trans) esterification to produce carboxylic ester motifs in moderate to good or excellent yields with good functional tolerance, such as that towards C-Br as well as C=C and C equivalent to C bonds. And complex 1 can be recycled six times without showing a significant decline in catalytic efficiency. It was demonstrated that cyclandelate, which is used to treat high blood pressure as well as heart and blood-vessel diseases, can be directly synthesized on a gram scale with 81% yield (6.70 g) using complex 1.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据