期刊
GREEN CHEMISTRY
卷 19, 期 18, 页码 4263-4267出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/c7gc01575e
关键词
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资金
- NIH [1S10OD012077]
A tandem deprotection/coupling sequence is reported for solution-phase peptide synthesis in water under micellar catalysis conditions using the designer surfactant TPGS-750-M. Cbz de-protection followed by peptide coupling in the presence of COMU and 2,6-lutidine afforded polypeptides containing up to 10 amino acid residues. A broad scope characterizes this new technology. No epimerization has been detected. The associated E Factors, as a measure of greenness and known to be extremely high for peptide couplings, have been reduced to less than 10 due to the step-economy and minimal amounts of organic solvent needed for product extraction.
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