期刊
GREEN CHEMISTRY
卷 19, 期 1, 页码 237-248出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/c6gc02334g
关键词
-
资金
- Fund for Scientific Research Flanders (FWO Vlaanderen)
- VITO (Vlaamse Instelling voor Technologisch Onderzoek)
- BOF (Bijzonder Onderzoeksfonds) of Ghent University
The industrial application of the Diels-Alder reaction for the atom-efficient synthesis of (hetero) cyclic compounds constitutes an important challenge. Safety and purity concerns, related to the instability of the polymerization prone diene and/or dienophile, limit the scalability of the production capacity of Diels-Alder products in a batch mode. To tackle these problems, the use of a high-pressure continuous microreactor process was considered. In order to increase the yields and the selectivity towards the endo-isomer, commercially available zeolites were used as a heterogeneous catalyst in a microscale packed bed reactor. As a result, a high conversion (>= 95%) and endo-selectivity (89 : 11) were reached for the reaction of cyclopentadiene and methyl acrylate, using a 1 : 1 stoichiometry. A throughput of 0.87 g h(-1) during at least 7 h was reached, corresponding to a 3.5 times higher catalytic productivity and a 14 times higher production of Diels-Alder adducts in comparison to the heterogeneous lab-scale batch process. Catalyst deactivation was hardly observed within this time frame. Moreover, complete regeneration of the zeolite was demonstrated using a straightforward calcination procedure.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据