期刊
出版社
IEEE
DOI: 10.1109/IMBIOC47321.2020.9385010
关键词
Electroporation; Pulsed Electric Field; Irregularly Shaped Cells; Perinuclear Space; Pore Radius Evolution
资金
- [B37H17005210007]
Electroporation technique is based on the perturbation of the cell membrane through the application of high-voltage electric pulses of short duration. In this paper, a non-linear dispersive model of the electroporation process in irregularly nucleated shaped cells is presented. In particular, the nuclear envelope was modeled as two lipid membranes separated by a perinuclear space. The dispersive properties of biological media was taken into account using a Debye-based relationship. The Multiphysics model solves simultaneously the Maxwell equations, the Smoluchowski equation, describing the creation and closure of pores, and the equations describing the temporal evolution of pore radius.
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