期刊
GLYCOBIOLOGY
卷 27, 期 7, 页码 595-598出版社
OXFORD UNIV PRESS INC
DOI: 10.1093/glycob/cwx035
关键词
branched-chain amino acids; insulin resistance; microbiome; mTOR; N-acetylglucosamine
资金
- Canadian Institutes of Health Research (CIHR) [MOP-62,975]
- Basic Research Fellowship from Parkinson Canada
Pedersen et al. (Pedersen HK, Gudmundsdottir V, Nielsen HB, Hyotylainen T, Nielsen T, Jensen BA, Forslund K, Hildebrand F, Prifti E, Falony G, et al. 2016. Human gut microbes impact host serum metabolome and insulin sensitivity. Nature. 535: 376-381.) report that human serum levels of branched-chain amino acids (BCAA) and N-acetylglucosamine (GlcNAc) increase in proportion to insulin resistance. They focus on the microbiome and the contributing subset of microbe species, thereby demonstrating disease causality in mice. As either oral GlcNAc or BCAA in mice are known to increase insulin resistance and weight gain, we note that recently published molecular data argues for a cooperative interaction.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据