期刊
GLOBAL SPINE JOURNAL
卷 11, 期 1, 页码 21-27出版社
SAGE PUBLICATIONS LTD
DOI: 10.1177/2192568219888446
关键词
tranexamic acid; spine surgery; local application; topical wash; blood loss
The study showed that both intravenous and local administration of tranexamic acid were effective in reducing intraoperative blood loss in instrumented spine surgeries. Local application of tranexamic acid had better postoperative blood conserving effects. This study is the first to detail the safety and efficacy of local infiltration of tranexamic acid in spine surgeries.
Study Design: Randomized control trial. Objective: The purpose of the study is to evaluate the safety and efficacy of tranexamic acid in reducing blood loss when administered through various routes in instrumented spine surgeries. Methods: A total of 104 patients undergoing instrumented spine surgery were randomly assigned to 4 groups (n = 26 in each group). Groups included (1) ivTXA-intravenous administration of tranexamic acid (TXA) 1 hour prior to surgery, (2) loTXA-local infiltration of TXA bilaterally into the paraspinal musculature prior to incision, (3) tTXA-topical application of TXA just before wound closure, and (4) control group. Outcome measures included intraoperative blood loss, postoperative blood loss, need for blood transfusion, length of hospital stay, and hematological parameters. Results: All the 3 different modes of TXA administration were found to be effective in reducing blood loss in the treated groups compared with the control group. Intraoperative blood loss was significantly reduced in ivTXA (223.6 +/- 40.1 mL, P < .0001) and loTXA (256.07 +/- 119 mL, P = .0039) groups when compared with controls (344 +/- 88.5 mL).The postoperative blood loss was least in tTXA followed by ivTXA, loTXA, and controls. There was 67% reduction in need for blood transfusion in tTXA group, 55.5% reduction in ivTXA group, and 33% reduction in loTXA group when compared with the control group. Conclusion: In instrumented spine surgery, ivTXA and loTXA were found to be equally effective in reducing the intraoperative blood loss. The tTXA has better postoperative blood conserving effects. This is the first study to detail about safety and efficacy on local infiltration of TXA in spine surgery, which is an effective and safe method for reducing intraoperative blood loss.
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