The Correlation BetweenHelicobacter pyloriInfection and Lnc-OC1 Expression in Gastric Cancer Tissues in an Iranian Population

Purpose The role of Lnc_OC1 in gastric cancer (GC) has not been well documented. The very purpose of the present study was to determine not only the expression of Lnc_OC1 in gastric tissues but also its role in the formation of GC. Furthermore, the expression levels of Lnc-OC1 were examined inH. pylori-positive versusH. pylori-negative GC tissues. Methods Tumor and adjacent normal tissues were collected from 43 patients with GC. RNA extraction and cDNA synthesis were performed. Then, qRT-PCR was carried out. Finally, an independent samplettest was run to examine the expression level of Lnc_OC1 in a GC and normal tissues using SPSS program. Results The results revealed a significantly higher expression level of Lnc_OC1 in the GC tissues as compared with the normal tissues (p = 0.0037). The correlations between the expression level of Lnc_OC1 and the clinical features of patients were not statistically significant (p > 0.05). Moreover, the expression of Lnc-OC1 was significantly higher inH. pylori-positive patients as compared withH. pylori-negative patients (p = 0.01). Conclusion The findings of the present study revealed that deregulation of Lnc_OC1 may have a role in theH. pylori-associated pathogenesis of GC. Moreover, a direct association can be speculated between GC formation and Lnc_OC1 expression. The mentioned findings highlight the potential role of Lnc_OC1 as a prognostic biomarker of GC. Hence, further evaluations are required in this respect.

Automated summary

The study found significantly higher expression of Lnc_OC1 in gastric cancer tissues compared to normal tissues, with no significant correlation with clinical features. Additionally, Lnc_OC1 expression was significantly higher in H. pylori-positive patients compared to H. pylori-negative patients.