期刊
GENOME RESEARCH
卷 27, 期 9, 页码 1608-1620出版社
COLD SPRING HARBOR LAB PRESS, PUBLICATIONS DEPT
DOI: 10.1101/gr.217463.116
关键词
-
资金
- Chinese Academy of Sciences [Y406541141, 1100050210, KJ2070000031]
- Ministry of Science and Technology of China [2015CB755605]
- National Science Foundation of China [91649119]
- National Science Foundation [91440108]
- Strategic Priority Research Program of CAS [XDB02020005]
- Appreciate the Beauty of Life, Inc. [ABL2015-02007]
- [81471312]
Long noncoding RNAs (lncRNAs) mediate important epigenetic regulation in a wide range of biological processes and diseases. We applied comprehensive analyses of RNA-seq and CAGE-seq (cap analysis of gene expression and sequencing) to characterize the dynamic changes in lncRNA expression in rhesus macaque (Macaca mulatta) brain in four representative age groups. We identified 18 anatomically diverse lncRNA modules and 14 mRNA modules representing spatial, age, and sex specificities. Spatiotemporal- and sex-biased changes in lncRNA expression were generally higher than those observed in mRNA expression. A negative correlation between lncRNA and mRNA expression in cerebral cortex was observed and functionally validated. Our findings offer a fresh insight into spatial-, age-, and sex-biased changes in lncRNA expression in macaque brain and suggest that the changes represent a previously unappreciated regulatory system that potentially contributes to brain development and aging.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据