期刊
GENOME BIOLOGY AND EVOLUTION
卷 9, 期 11, 页码 3073-3087出版社
OXFORD UNIV PRESS
DOI: 10.1093/gbe/evx212
关键词
FA-SAT; satellite DNA; Bilateria genomes; satellite DNA transcription
资金
- Science and Technology Foundation (FCT) from Portugal [SFRH/BD/80446/2011, SFRH/BD/80808/2011, SFRH/BD/41576/2007, POCTI/C_BIA/11285/98, POCI/CVT/62940/04, POCI/ BIA_BCM/58541/04]
- BioISI project [UID/Multi/04046/2013]
- Fundação para a Ciência e a Tecnologia [SFRH/BD/80446/2011, SFRH/BD/41576/2007, SFRH/BD/80808/2011] Funding Source: FCT
In recent years, a growing body of evidence has recognized the tandem repeat sequences, and specifically satellite DNA, as a functional class of sequences in the genomic dark matter. Using an original, complementary, and thus an eclectic experimental design, we show that the cat archetypal satellite DNA sequence, FA-SAT, is frozen conservatively in several Bilateria genomes. We found different genomic FA-SAT architectures, and the interspersion pattern was conserved. In Carnivora genomes, the FA-SAT-related sequences are also amplified, with the predominance of a specific FA-SAT variant, at the heterochromatic regions. We inspected the cat genome project to locate FA-SAT array flanking regions and revealed an intensive intermingling with transposable elements. Our results also show that FA-SAT-related sequences are transcribed and that the most abundant FA-SAT variant is not always the most transcribed. We thus conclude that the DNA sequences of FA-SAT and their transcripts are frozen in these genomes. Future work is needed to disclose any putative function that these sequences may play in these genomes.
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