期刊
GENOME BIOLOGY AND EVOLUTION
卷 10, 期 1, 页码 45-55出版社
OXFORD UNIV PRESS
DOI: 10.1093/gbe/evx268
关键词
Bruges orthohantavirus; Bunyavirales; coinfection; Talpa europaea; virus-host interaction; zoonosis
资金
- KU Leuven [IDO/07/005, CREA/11/027]
- Slovak Research and Development Agency [APVV-15-0232]
- U.S. Public Health Service grant from the National Institute of Allergy and Infectious Diseases [R01AI075057]
- National Institute of General Medical Sciences, National Institutes of Health [P20GM103516]
Hantaviruses are zoonotic viruses with a complex evolutionary history of virus-host coevolution and cross-species transmission. Although hantaviruses have a broad reservoir host range, virus-host relationships were previously thought to be strict, with a single virus species infecting a single host species. Here, we describe Bruges virus, a novel hantavirus harbored by the European mole (Talpa europaea), which is the well-known host of Nova virus. Phylogenetic analyses of all three genomic segments showed tree topology inconsistencies, suggesting that Bruges virus has emerged from cross-species transmission and ancient reassortment events. A high number of coinfections with Bruges and Nova viruses was detected, but no evidence was found for reassortment between these two hantaviruses. These findings highlight the complexity of hantavirus evolution and the importance of further investigation of hantavirus-reservoir relationships.
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