期刊
ENDOCRINE
卷 72, 期 2, 页码 358-374出版社
SPRINGER
DOI: 10.1007/s12020-020-02436-9
关键词
Endocrine disruptors; Male reproductive health; Testicular function; Testicular cancer
资金
- TALENT Study Group, Sapienza University of Rome, Italy
- Universita degli Studi di Roma La Sapienza within the CRUI-CARE Agreement
Information on the consequences of EDs exposure in current literature is limited and often conflicting, due to the scarcity of human studies and their heterogeneity. Despite controversial results, the overall conclusion points towards a positive association between exposure to EDs and reproductive system damage. Further long-term studies involving a wide range of subjects are necessary to identify damaging compounds and remove them from the environment.
Purpose Endocrine disruptors (EDs) are exogenous substances able to impair endocrine system; consequently, they may cause numerous adverse effects. Over the last years, particular focus has been given to their harmful effects on reproductive system, but very little is known, especially in males. The aim of this review is to discuss the detrimental effects of EDs exposure on fetal testis development, male puberty, and transition age. Methods A search for the existing literature focusing on the impact of EDs on fetal testis development, male puberty, andrological parameters (anogenital distance, penile length, and testicular volume), and testicular cancer with particular regard to pubertal age provided the most current information available for this review. Human evidence-based reports were given priority over animal and in vitro experimental results. Given the paucity of available articles on this subject, all resources were given careful consideration. Results Information about the consequences associated with EDs exposure in the current literature is limited and often conflicting, due to the scarcity of human studies and their heterogeneity. Conclusions We conclude that current evidence does not clarify the impact of EDs on human male reproductive health, although severe harmful effects had been reported in animals. Despite controversial results, overall conclusion points toward a positive association between exposure to EDs and reproductive system damage. Further long-term studies performed on wide number of subjects are necessary in order to identify damaging compounds and remove them from the environment.
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