期刊
STEM CELL REVIEWS AND REPORTS
卷 17, 期 2, 页码 379-389出版社
SPRINGER
DOI: 10.1007/s12015-020-10023-8
关键词
Tendon injuries; Tendon repair; Tendon-to-bone junction injuries; Tendon-to-bone junction repair; Tissue engineering; Stem cell-based therapy; Extracellular vesicles; Exosomes; Microvesicles; Mesenchymal stem cells
Tendon injuries are common in physical activities, and the healing process is slow. Mesenchymal stem cell-derived extracellular vesicles have been shown to promote tendon repair by secreting paracrine factors, offering a new treatment strategy for this soft tissue disorder.
Tendon injuries are prevalent in physical activities and sports. Tendon heals slowly after injuries. The results of conservative treatments and surgery are not satisfactory with high re-injury rate and scar tissue formation. The application of mesenchymal stem cells (MSCs) to the injured tendons was reported to promote tendon repair. Recent studies have suggested that MSCs supported tendon repair via the secretion of paracrine factors. Extracellular vesicles (EVs) are a heterogeneous group of cell-derived membranous structures that are produced and secreted by most eukaryotic cells. They carry a plethora of proteins, lipids, microRNA and mRNA which reprogram the recipient cells and are involved in multiple physiological and pathological processes. EVs were shown to promote tissue repair and mediate the healing effects of MSCs. In this review, I aim to review the recent literature on the promotion of tendon repair using EVs-derived from MSCs (MSC-EVs). The mechanisms underlying these actions are also reviewed and future research directions are discussed. Better understanding of the roles of MSC-EVs in tendon repair would offer a new treatment strategy to circumvent this devastating soft tissue disorder.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据