期刊
GENETICS
卷 205, 期 1, 页码 5-24出版社
GENETICS SOCIETY AMERICA
DOI: 10.1534/genetics.115.185132
关键词
FlyBook; genome architecture; chromatin insulators; epigenetics
资金
- European Horizon [676556]
- European Network of Excellence EpiGeneSys
- Centre National de la Recherche Scientifique
- Agence Nationale de la Recherche (EpiDevoMath)
- Fondation pour la Recherche Medicale [DEI20151234396]
- Institut National de la Sante et de la Recherche Medicale/Plan Cancer Epigenetics and Cancer Program (MMTT)
- Laboratory of Excellence EpiGenMed
- Fondation ARC pour la Recherche sur le Cancer
- Swedish Research Council
- Knut and Alice Wallenberg Foundation
- Cancerfonden
- Kempestiftelserna
- Umea University Insamlingsstiftelsen
Understanding how the metazoan genome is used during development and cell differentiation is one of the major challenges in the postgenomic era. Early studies in Drosophila suggested that three-dimensional (3D) chromosome organization plays important regulatory roles in this process and recent technological advances started to reveal connections at the molecular level. Here we will consider general features of the architectural organization of the Drosophila genome, providing historical perspective and insights from recent work. We will compare the linear and spatial segmentation of the fly genome and focus on the two key regulators of genome architecture: insulator components and Polycomb group proteins. With its unique set of genetic tools and a compact, well annotated genome, Drosophila is poised to remain a model system of choice for rapid progress in understanding principles of genome organization and to serve as a proving ground for development of 3D genome-engineering techniques.
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