期刊
GENETICS
卷 205, 期 4, 页码 1677-1689出版社
GENETICS SOCIETY AMERICA
DOI: 10.1534/genetics.116.196154
关键词
Deinococcus radiodurans; gamma radiation; genome stability; gene order; synteny
资金
- Croatian Science Foundation [IP-11-2013-2978]
- Medical Research Counci
- Imperial College Junior Research Fellowship
- Spanish Ministry of Economy and Competitiveness, 'Centro de Excelencia Severo Ochoa'
- CERCA Programme/Generalitat de Catalunya
- Medical Research Council [MC_UP_1102/7] Funding Source: researchfish
- MRC [MC_UP_1102/7] Funding Source: UKRI
A number of bacterial, archaeal, and eukaryotic species are known for their resistance to ionizing radiation. One of the challenges these species face is a potent environmental source of DNA double-strand breaks, potential drivers of genome structure evolution. Efficient and accurate DNA double-strand break repair systems have been demonstrated in several unrelated radiation-resistant species and are putative adaptations to the DNA damaging environment. Such adaptations are expected to compensate for the genome-destabilizing effect of environmental DNA damage and may be expected to result in a more conserved gene order in radiation-resistant species. However, here we show that rates of genome rearrangements, measured as loss of gene order conservation with time, are higher in radiation-resistant species in multiple, phylogenetically independent groups of bacteria. Comparison of indicators of selection for genome organization between radiation-resistant and phylogenetically matched, nonresistant species argues against tolerance to disruption of genome structure as a strategy for radiation resistance. Interestingly, an important mechanism affecting genome rearrangements in prokaryotes, the symmetrical inversions around the origin of DNA replication, shapes genome structure of both radiation-resistant and nonresistant species. In conclusion, the opposing effects of environmental DNA damage and DNA repair result in elevated rates of genome rearrangements in radiation-resistant bacteria.
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