Microglia-associated neuroinflammation is a potential therapeutic target for ischemic stroke

Microglia-associated neuroinflammation plays an important role in the pathophysiology of ischemic stroke. Microglial activation and polarization, and the inflammatory response mediated by these cells play important roles in the development, progression and outcome of brain injury after ischemic stroke. Currently, there is no effective strategy for treating ischemic stroke in clinical practice. Therefore, it is clinically important to study the role and regulation of microglia in stroke. In this review, we discuss the involvement of microglia in the neuroinflammatory process in ischemic stroke, with the aim of providing a better understanding of the relationship between ischemic stroke and microglia.

Automated summary

Microglia play a crucial role in the pathophysiology of ischemic stroke, with their activation, polarization, and inflammatory response being important factors in the development and outcome of brain injury following strokes. Studies on microglial involvement in neuroinflammation provide a better understanding of the relationship between ischemic stroke and microglia, as there is currently no effective clinical strategy for treating ischemic stroke.