期刊
NEURAL REGENERATION RESEARCH
卷 16, 期 1, 页码 80-92出版社
WOLTERS KLUWER MEDKNOW PUBLICATIONS
DOI: 10.4103/1673-5374.286955
关键词
-
资金
- National Natural Science Foundation of China [81471308]
- Program of China National Health Commission [CMR-20161129-1003]
- National Medical Products Administration (NMPA) [CMR-20161129-1003]
- Liaoning Province Excellent Talent Program Project [XLYC1902031]
- Dalian Innovation Fund [2018J11CY025]
Stroke is a leading cause of death and disability worldwide. Stem cell-based interventions, particularly neural stem cells, show promise in substantial recovery of brain function after stroke. Neural stem cells play a crucial role in neurological repair, offering unique advantages in cell replacement, paracrine action, inflammatory regulation, and neuroprotection.
Stroke is a main cause of death and disability worldwide. The ability of the brain to self-repair in the acute and chronic phases after stroke is minimal; however, promising stem cell-based interventions are emerging that may give substantial and possibly complete recovery of brain function after stroke. Many animal models and clinical trials have demonstrated that neural stem cells (NSCs) in the central nervous system can orchestrate neurological repair through nerve regeneration, neuron polarization, axon pruning, neurite outgrowth, repair of myelin, and remodeling of the microenvironment and brain networks. Compared with other types of stem cells, NSCs have unique advantages in cell replacement, paracrine action, inflammatory regulation and neuroprotection. Our review summarizes NSC origins, characteristics, therapeutic mechanisms and repair processes, then highlights current research findings and clinical evidence for NSC therapy. These results may be helpful to inform the direction of future stroke research and to guide clinical decision-making.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据