期刊
NATURE REVIEWS IMMUNOLOGY
卷 21, 期 3, 页码 162-176出版社
NATURE PORTFOLIO
DOI: 10.1038/s41577-020-00426-6
关键词
-
类别
资金
- Japan Society for the Promotion of Science KAKENHI [JP19H03692]
- Mochida Memorial Foundation for Medical and Pharmaceutical Research
- Naito Foundation
- Takeda Science Foundation
- US Public Health Service [R01AI135200, R01HL119102, R01HD100039, R01HD076915]
- Albert Billings Ruddock Professorship
Transcription factors play essential roles in early thymic development to establish T cell lineage identity by controlling the activities of specific genomic loci. The interactions between inherited epigenetic states, transcription factor-DNA binding affinity thresholds, and influences of given transcription factors on other factors in the same cells determine T cell identity and make the lineage choice irreversible.
Recent evidence has elucidated how multipotent blood progenitors transform their identities in the thymus and undergo commitment to become T cells. Together with environmental signals, a core group of transcription factors have essential roles in this process by directly activating and repressing specific genes. Many of these transcription factors also function in later T cell development, but control different genes. Here, we review how these transcription factors work to change the activities of specific genomic loci during early intrathymic development to establish T cell lineage identity. We introduce the key regulators and highlight newly emergent insights into the rules that govern their actions. Whole-genome deep sequencing-based analysis has revealed unexpectedly rich relationships between inherited epigenetic states, transcription factor-DNA binding affinity thresholds and influences of given transcription factors on the activities of other factors in the same cells. Together, these mechanisms determine T cell identity and make the lineage choice irreversible.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据