期刊
NATURE REVIEWS IMMUNOLOGY
卷 21, 期 5, 页码 277-291出版社
NATURE PORTFOLIO
DOI: 10.1038/s41577-020-00457-z
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资金
- US National Cancer Institute [R01-CA228358, R01-CA228308, R01-HL147584, P30-CA008748, P01-CA023766]
- US National Heart, Lung, and Blood Institute [R01-HL125571, R01-HL123340]
- US National Institute on Aging [P01-AG052359]
- Tri-Institutional Stem Cell Initiative [2016-013]
- US National Institute of Allergy and Infectious Diseases [U01-AI124275]
- Italian Association for Cancer Research
- Italian Ministry of Health (Ricerca Corrente programme)
- Society of Memorial Sloan Kettering Cancer Center Scholars Award
- Lymphoma Foundation
- Amy Strelzer Manasevit Research Program
- Susan and Peter Solomon Divisional Genomics Program
- Parker Institute for Cancer Immunotherapy at Memorial Sloan Kettering Cancer Center
- Seres Therapeutics
This article discusses the importance of immune reconstitution, specifically of T cells, following periods of haematopoietic cell stress. Delayed or defective recovery of T cells can have significant clinical consequences, highlighting the need for therapeutic strategies to restore immune function.
Following periods of haematopoietic cell stress, such as after chemotherapy, radiotherapy, infection and transplantation, patient outcomes are linked to the degree of immune reconstitution, specifically of T cells. Delayed or defective recovery of the T cell pool has significant clinical consequences, including prolonged immunosuppression, poor vaccine responses and increased risks of infections and malignancies. Thus, strategies that restore thymic function and enhance T cell reconstitution can provide considerable benefit to individuals whose immune system has been decimated in various settings. In this Review, we focus on the causes and consequences of impaired adaptive immunity and discuss therapeutic strategies that can recover immune function, with a particular emphasis on approaches that can promote a diverse repertoire of T cells through de novo T cell formation. Reconstitution of the immune system after depletion by chemotherapy, radiotherapy, infection or transplantation is crucial to maintain protection from infection and to respond to immune-based therapy. Here the authors describe the ways in which a diverse T cell compartment can be restored, focusing on therapeutic strategies that drive the production of new T cells.
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