期刊
GEROSCIENCE
卷 43, 期 2, 页码 985-1001出版社
SPRINGER
DOI: 10.1007/s11357-020-00287-w
关键词
GDF15; FGF21; Humanin; Aging; AD; T2D
资金
- Alma Mater Studiorum - Universita di Bologna within the CRUI-CARE Agreement
- Roberto and Cornelia Pallotti Legacy for Cancer Research
- worldclass scientific center - the Center for Photonics of the Russian National Project Science
- Italian Ministry of Health Ricerca Finalizzata Young Researchers (under 40)-Giovani Ricercatori [GR-2013-02358026]
- JPIHDHL-Metadis, EURODIET project [1164]
- Italian Ministry of Health (Ricerca Corrente)
FGF21, GDF15, and HN are mitokines related to mitochondrial stress and positively correlated with age, showing different expressions in type 2 diabetes and Alzheimer's disease, suggesting FGF21 as a candidate marker of healthy aging.
Fibroblast Growth Factor 21 (FGF21), Growth Differentiation Factor 15 (GDF15), and Humanin (HN) are mitochondrial stress-related mitokines, whose role in health and disease is still debated. In this study, we confirmed that their plasma levels are positively correlated with age in healthy subjects. However, when looking at patients with type 2 diabetes (T2D) or Alzheimer's disease (AD), two age-related diseases sharing a mitochondrial impairment, we found that GDF15 is elevated in T2D but not in AD and represents a risk factor for T2D complications, while FGF21 and HN are lower in AD but not in T2D. Moreover, FGF21 reaches the highest levels in centenarian' offspring, a model of successful aging. As a whole, these data indicate that (i) the adaptive mitokine response observed in healthy aging is lost in age-related diseases, (ii) a common expression pattern of mitokines does not emerge in T2D and AD, suggesting an unpredicted complexity and disease-specificity, and (iii) FGF21 emerges as a candidate marker of healthy aging.
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