期刊
GENES & DEVELOPMENT
卷 31, 期 18, 页码 1827-1840出版社
COLD SPRING HARBOR LAB PRESS, PUBLICATIONS DEPT
DOI: 10.1101/gad.305805.117
关键词
blood-based diagnostics; cancer metastasis; circulating tumor cells
资金
- National Institutes of Health [2RO1CA129933]
- Howard Hughes Medical Institute
- Breast Cancer Research Foundation
- National Foundation for Cancer Research
Advances in the enrichment and analysis of rare cells from the bloodstreamhave allowed for detection and characterization of circulating tumor cells (CTCs) from patients with cancer. The analysis of CTCs has provided significant insight into the metastatic process. Studies on the biology of CTCs have begun to elucidate the molecular mechanisms of CTC generation, intravasation, survival, interactions with components of the blood, extravasation, and colonization of distant organs. Additionally, the study of CTCs has exposed dramatic intrapatient and interpatient heterogeneity and their evolution over time. In this review, we focus on the current knowledge of CTC biology and the potential clinical implications.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据