期刊
GENES & DEVELOPMENT
卷 31, 期 11, 页码 1073-1088出版社
COLD SPRING HARBOR LAB PRESS, PUBLICATIONS DEPT
DOI: 10.1101/gad.298232.117
关键词
MCM2-7; DNA replication; pre-RC; CMG; replisome; cryo-EM
资金
- Biotechnology and Biological Sciences Research Council [BB/M003760/1, BB/N000323/1]
- Medical Research Council [MC_U120085811]
- Wellcome Trust [107903/Z/15/Z]
- Biotechnology and Biological Sciences Research Council [BB/M003760/1, BB/N000323/1] Funding Source: researchfish
- Medical Research Council [MC_U120085811, 1583051] Funding Source: researchfish
- Wellcome Trust [107903/Z/15/Z] Funding Source: researchfish
- Wellcome Trust [107903/Z/15/Z] Funding Source: Wellcome Trust
- BBSRC [BB/N000323/1, BB/M003760/1] Funding Source: UKRI
- MRC [MC_U120085811] Funding Source: UKRI
DNAreplication results in the doubling of the genome prior to cell division. This process requires the assembly of 50 or more protein factors into a replication fork. Here, we review recent structural and biochemical insights that start to explain how specific proteins recognize DNA replication origins, load the replicative helicase on DNA, unwind DNA, synthesize newDNAstrands, and reassemble chromatin. We focus on the minichromosome maintenance (MCM2-7) proteins, which form the core of the eukaryotic replication fork, as this complex undergoes major structural rearrangements in order to engage with DNA, regulate its DNA-unwinding activity, and maintain genome stability.
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