期刊
JOURNAL OF BIOLOGICAL RHYTHMS
卷 36, 期 1, 页码 9-22出版社
SAGE PUBLICATIONS INC
DOI: 10.1177/0748730420967768
关键词
circadian rhythm; viruses; COVID-19; virus-clock; virology
资金
- Wellcome Trust [IA 200838/Z/16/Z]
- MRC [MR/R022011/1]
- Wellcome Trust DPhil program in Infection, Immunology and Translational Medicine
- MRC [MR/R022011/1] Funding Source: UKRI
The circadian clock is crucial for regulating virus infections and host responses, providing opportunities for novel antiviral therapies.
The circadian clock controls several aspects of mammalian physiology and orchestrates the daily oscillations of biological processes and behavior. Our circadian rhythms are driven by an endogenous central clock in the brain that synchronizes with clocks in peripheral tissues, thereby regulating our immune system and the severity of infections. These rhythms affect the pharmacokinetics and efficacy of therapeutic agents and vaccines. The core circadian regulatory circuits and clock-regulated host pathways provide fertile ground to identify novel antiviral therapies. An increased understanding of the role circadian systems play in regulating virus infection and the host response to the virus will inform our clinical management of these diseases. This review provides an overview of the experimental and clinical evidence reporting on the interplay between the circadian clock and viral infections, highlighting the importance of virus-clock research.
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