期刊
GENES & DEVELOPMENT
卷 31, 期 12, 页码 1180-1194出版社
COLD SPRING HARBOR LAB PRESS, PUBLICATIONS DEPT
DOI: 10.1101/gad.301325.117
关键词
DNA damage; nervous system; genome stability; neurodevelopment; neurologic disease
资金
- National Institutes of Health [NS-37956, CA-21765]
- Cancer Center Support Grant [P30 CA21765]
- American Lebanese and Syrian Associated Charities of St. Jude Children's Research Hospital
Multiple DNA repair pathways maintain genome stability and ensure that DNA remains essentially unchanged over the life of a cell. Various human diseases occur if DNA repair is compromised, and most of these impact the nervous system, in some cases exclusively. However, it is often unclear what specific endogenous damage underpins disease pathology. Generally, the types of causative DNA damage are associated with replication, transcription, or oxidative metabolism; other direct sources of endogenous lesions may arise from aberrant topoisomerase activity or ribonucleotide incorporation into DNA. This review focuses on the etiology of DNA damage in the nervous system and the genome stability pathways that prevent human neurologic disease.
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