期刊
GENES & DEVELOPMENT
卷 31, 期 8, 页码 719-720出版社
COLD SPRING HARBOR LAB PRESS, PUBLICATIONS DEPT
DOI: 10.1101/gad.300491.117
关键词
sumoylation; desumoylation; STUbL; monopolin; cohibin; rDNA silencing; RENT complex
资金
- National Institutes of Health [GM080670]
SUMO homeostasis is important for many cellular processes. In the current issue of Genes & Development, Liang and colleagues (pp. 802-815) demonstrate how a desumoylation enzyme is targeted to the nucleolus for removing SUMO from specific substrates and how curtailing sumoylation levels can regulate transcription in this nuclear compartment.
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