Some data on the comparative and combined toxic activity of nanoparticles containing lead and cadmium with special attention to their vasotoxicity

Moderate subchronic intoxication was induced in rats by repeated intraperitoneal injections of PbO (49.6 +/- 16.0 nm) and/or CdO (57.0 +/- 13.0 nm) nanoparticles (NP) three times a week during 6 weeks. In particular, there was a reduction in arterial blood pressure and in blood concentrations of a number of factors controlling vasoconstriction and vasodilation, particularly of endothelin 1 (ET-1). This toxic effect was attenuated with a bioprotective complex administered in the background. The study confirmed as well that the combined binary action typology varies depending on which effect it is estimated by.

Automated summary

Moderate subchronic intoxication in rats can be induced by repeated intraperitoneal injections of PbO and/or CdO nanoparticles, leading to reductions in blood pressure and levels of factors controlling vasoconstriction and vasodilation.