期刊
ADVANCED FUNCTIONAL MATERIALS
卷 31, 期 8, 页码 -出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/adfm.202007991
关键词
cytochrome c oxidase; H; S-2; nanocatalytic medicine; photothermal; reactive oxygen species
类别
资金
- National Natural Science Foundation of China [32030061, 51772316]
- Key Program for Basic Research of Shanghai [19JC1415600]
- Key Project of International Cooperation and Exchange of NSFC [81720108023]
- Opening Project of State Key Laboratory of High-Performance Ceramics and Superfine Microstructure [SKL201908SIC]
By developing novel nanoparticles combined with photothermal and gas therapy, tumor growth can be inhibited in the tumor environment, opening up a new approach for the design of gas-mediated cancer treatment.
Nanocatalytic medicine has emerged as a promising method for the specific cancer therapy by mediating the interaction between tumor microenvironment biomarkers and nanoagents. However, the produced antitumor cell killing molecules, such as reactive oxygen species (ROS), by catalysis are insufficient to inhibit tumor growth. Herein, a novel kind of polyvinyl pyrrolidone modified multifunctional iron sulfide nanoparticles (Fe1-xS-PVP NPs) is developed via a one-step hydrothermal method, which exhibits high photothermal (PT) conversion efficiency (eta = 24%) under the irradiation of 808 nm near-infrared laser. The increased temperature further facilitates the Fenton reaction to generate abundant center dot OH radicals. More importantly, under an acidic (pH = 6.5) condition within tumor environment, the Fe1-xS-PVP NPs can in situ produce H2S gas, which is evidenced to suppress the activity of enzyme cytochrome c oxidase (COX IV) in cancer cells, contributing to inhibit the growth of tumor. Both in vitro and in vivo results demonstrate that the H2S-mediated gas therapy in combination with PT enhanced ROS achieves excellent antitumor performance, which can open up a new approach for the design of gas-mediated cancer treatment.
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