期刊
ADVANCED FUNCTIONAL MATERIALS
卷 31, 期 12, 页码 -出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/adfm.202008352
关键词
antiviral; biomimetic; COVID-19; nanomaterials; therapy; vaccine; virus
类别
资金
- National Research Foundation of Korea (NRF) - Korean government (MSIT) [2020R1C1C1004385, 2019R1A2C2004765]
- 1000 Foreign Experts Program from the National Natural Science Foundation, China [WQ2017420438]
- Korea Research Fellowship Program through the National Research Foundation of Korea (NRF) - Ministry of Science and ICT [2019H1D3A1A01070318]
This article discusses the importance of developing nanomaterials for the treatment and prevention of viral infections, as well as the latest advances in biomimetic nanomaterials in this field, mainly covering nanomaterial-enhanced viral replication inhibitors, biomimetic virus particle capture schemes, and nanoparticle vaccines.
The ongoing coronavirus disease 2019 (COVID-19) pandemic highlights the importance of developing effective virus targeting strategies to treat and prevent viral infections. Since virus particles are nanoscale entities, nanomaterial design strategies are ideally suited to create advanced materials that can interact with and mimic virus particles. In this progress report, the latest advances in biomimetic nanomaterials are critically discussed for combating viral infections, including in the areas of nanomaterial-enhanced viral replication inhibitors, biomimetic virus particle capture schemes, and nanoparticle vaccines. Particular focus is placed on nanomaterial design concepts and material innovations that can be readily developed to thwart future viral threats. Pertinent nanomaterial examples from the COVID-19 situation are also covered along with discussion of human clinical trial efforts underway that might lead to next-generation antiviral therapies and vaccines.
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