期刊
CANCER MEDICINE
卷 10, 期 1, 页码 257-268出版社
WILEY
DOI: 10.1002/cam4.3592
关键词
hypoxia; photodynamic therapy; reactive oxygen species; ROS defense system; tumor treatment
类别
资金
- National Natural Science Foundation of China [81602728]
- Natural Science Foundation of Jiangsu Province [BK20171148]
- Jiangsu Graduate Scientific Research Innovation Program [KYCX20_1433]
- Jiangsu Health Commission [H2018114]
- Project 333 Scientific Research Project Grant Scheme of Jiangsu Province [BRA2019024]
The article summarizes both common and innovative strategies used in recent years to enhance the killing capacity of ROS on tumors, including methods to address hypoxia in the tumor microenvironment and innovative approaches to inhibit the ROS defense system.
In the process of photodynamic therapy (PDT) treatment of tumors, reactive oxygen species (ROS) plays a key role in destroying tumor tissues. However, traditional PDT often has limited ROS killing capacity due to hypoxia in the tumor microenvironment (TME) or obstruction by the ROS defense system, resulting in poor efficacy. Therefore, enhancing the killing effect of ROS on tumors is the core of enhancing the anti-tumor effect of PDT. In recent years, many studies have developed a series of strategies to enhance the ability of ROS to kill tumors in view of the limitations of the TME on PDT. This article summarizes the commonly used or innovative strategies in recent years, including not only frequently used methods for hypoxia in the TME but also innovative strategies to inhibit the ROS defense system.
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