期刊
OBESITY SURGERY
卷 31, 期 3, 页码 1158-1167出版社
SPRINGER
DOI: 10.1007/s11695-020-05098-8
关键词
Bariatric surgery; Sleeve gastrectomy; Roux-en-Y gastric bypass; Fibrin glue; Fibrin sealants; Reinforcement
类别
This meta-analysis assessed the effectiveness of fibrin sealant in reducing complications after bariatric surgery, finding that it significantly reduced bleeding incidence but did not have a significant impact on leakage, gastric stricture, reoperation rate, or length of hospital stay. The study suggests that while fibrin sealants may provide favorable results in bariatric surgery, further research is needed to determine their efficacy in reducing postoperative complications.
Background Complications including staple-line leakage and bleeding may occur after sleeve gastrectomy and Roux-en-Y gastric bypass. In this meta-analysis, the efficacy of fibrin sealant in strengthening the staple line and reducing complication risk after bariatric surgery was evaluated. Methods We searched PubMed, Embase, and Cochrane Library databases for randomized controlled trials (RCTs) published up to October 2020. Pooled estimates of the outcomes were computed using a random effects model. The primary outcomes were bleeding and leakage; secondary outcomes were gastric stricture, length of hospital stay, reoperation rate, and total operation time. Results In total, 9 RCTs including 2136 patients were reviewed. Our meta-analysis revealed that compared with controls, fibrin sealants decreased incidence of bleeding significantly (risk ratio [RR] = 0.42; 95% confidence interval [CI], 0.18-0.97), but did not demonstrate significant differences in reducing the incidence of leakage (RR = 0.62; 95% CI, 0.23-1.73), gastric stricture (RR = 1.16; 95% CI, 0.46-2.91), reoperation rate (RR = 0.85; CI, 0.14-5.14), or length of hospital stay (weighted mean difference = 0.62; 95% CI, - 0.31 to 1.55). Compared with oversewing, fibrin sealant use reduced the operation time; however, their efficacies in reducing the incidence of postoperative bleeding and leakage did not differ significantly. Conclusions Although applying fibrin sealants to the staple line in bariatric surgery may provide favorable results, but it may not reduce postoperative leakage and stricture incidence significantly. Nevertheless, the application of fibrin sealants as a method for reducing risks of complications after bariatric surgery warrant further investigation.
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