Baseline Hypothalamic-Pituitary-Adrenal Axis and Parasympathetic Nervous System Activity Interact to Predict Executive Functions in Low-Income Children

We examined interactions between baseline hypothalamic-pituitary-adrenal (HPA) axis and parasympathetic nervous system (PNS) activity in relation to executive functions (EF) in a sample (n = 1,005) of children in low wealth, nonurban communities at age 48 months. Salivary cortisol and respiratory sinus arrhythmia (RSA) represented baseline HPA axis and PNS activity, respectively. The interaction between RSA and cortisol predicted EF such that children with either lower RSA and lower cortisol, or higher RSA and higher cortisol had higher EF scores. These findings suggest a potential compensatory relation in which the PNS and HPA axis counterbalance each other to support cognition.

Automated summary

The study revealed interactions between baseline hypothalamic-pituitary-adrenal (HPA) axis and parasympathetic nervous system (PNS) activity in 48-month-old children, impacting their executive functions. The findings suggest a potential compensatory relationship between PNS and HPA axis in supporting cognition.