期刊
GENERAL AND COMPARATIVE ENDOCRINOLOGY
卷 245, 期 -, 页码 122-126出版社
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.ygcen.2016.08.010
关键词
Endocrine disruptors; Epigenetic; Environmental toxins; Female fertility; Reproduction; DNA methylation; Histone modifications
Epigenetic modifications are classified as heritable and reversible chemical modifications of chromatin that do not cause changes in DNA sequence. Changes in epigenetic modifications can be caused by exposure to certain environmental factors, such as contaminants like bisphenol A (BPA). Bisphenol A is ubiquitous in the environment and produced in large quantities, and known to have hormone-like activity, whereby disrupting endocrine function. Because of evidence for disruption of sex steroid mediated pathways, there is a concern that BPA could have adverse effects on female reproduction. The purpose of this review is to summarize the effects of BPA on adult female reproduction with focus on epigenetic changes that can be heritable. (C) 2016 Elsevier Inc. All rights reserved.
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