4.6 Article

Interferon alpha for essential thrombocythemia during 34 high-risk pregnancies: outcome and safety

期刊

出版社

SPRINGER
DOI: 10.1007/s00432-020-03430-4

关键词

Essential thrombocythemia; Pregnancies; Interferon alpha; Outcome; Safety

类别

向作者/读者索取更多资源

This study analyzed data from 23 women with high-risk ET pregnancies, finding that the use of IFN significantly increased the live birth rate to 73.5% with no fatal maternal events and manageable side effects.
Purpose Pregnancies in women with essential thrombocythemia (ET) are at a higher risk for obstetrical complications. Acetylsalicylic acid (ASA) and low-molecular weight heparin (LMWH) are common options to prevent miscarriages and maternal complications, whereas interferon alpha (IFN) seems to be the cytoreductive therapy of choice. This retrospective study analyzes the largest number of IFN pregnancies to date in terms of outcome and safety. Methods Data of 34 high-risk pregnancies in 23 women presenting at the University hospitals of Minden and Jena from 01-Jun-2007 to 01-Jun-2020 were collected. Reasons defining high-risk ET pregnancy in all 23 patients were: Thrombosis (n = 9) or severe hemorrhage (n = 2) in history, platelet count >= 1500 x 10(3)/mu l (n = 8) or severe microcirculatory disturbances not completely responding to ASA (n = 4). Results Without the use of IFN, live birth rate was 60% (6/10), however, after the use of IFN live birth rate increased to 73.5% (25/34 pregnancies). Nine pregnancies ended in miscarriages (9/34; 26.5%); all of them spontaneous abortions. Live birth rate significantly improved with ASA (90% versus 50%, p = 0.0168), however, if ASA and LMWH was added (n = 14), live birth rate was 100%. IFN compound (PEGylated versus standard IFN) and JAK2-driver mutation had no impact on pregnancy outcome. One major maternal complication occurred as a major peripartal bleeding after abortion curettage. Conclusion IFN was associated with an encouraging live birth rate of 73.5% with no fatal maternal events and manageable side effects.

作者

我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。

评论

主要评分

4.6
评分不足

次要评分

新颖性
-
重要性
-
科学严谨性
-
评价这篇论文

推荐

暂无数据
暂无数据