期刊
INFLAMMATION
卷 44, 期 3, 页码 846-858出版社
SPRINGER/PLENUM PUBLISHERS
DOI: 10.1007/s10753-020-01379-7
关键词
Porphyromonas gingivalis; lipopolysaccharide; fibroblast; programmed cell death; pyroptosis
资金
- Finance Department of Jilin Province [JCSZ2019378-3, JCSZ2020304-24]
- Department of Science and Technology of Jilin Province [20180101121JC, 20200404108YY]
The study found that P. gingivalis-LPS can induce pyroptosis in human gingival fibroblasts, exacerbating the inflammatory response of periodontitis, and similar results were observed in animal models.
Periodontitis is a chronic inflammatory disease induced by Porphyromonas gingivalis (P. gingivalis) and other pathogens. P. gingivalis release various virulence factors including lipopolysaccharide (LPS). However, whether P. gingivalis-LPS inducing pyroptosis in human gingival fibroblasts (HGFs) remains unknown. In present study, P. gingivalis-LPS decreased the membrane integrity of HGFs, and pyroptosis-associated cytokines were upregulated at the mRNA level. In addition, pyroptosis proteins were highly expressed in gingival tissues of periodontitis. P. gingivalis-LPS induced gingivitis in the rat model, and the expression level of pyroptosis-associated proteins increased. Together, P. gingivalis-LPS can activate the pyroptosis reaction, which may be a pro-pyroptosis status in a relative low concentration.
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