期刊
JOURNAL OF SURGICAL ONCOLOGY
卷 123, 期 2, 页码 544-552出版社
WILEY
DOI: 10.1002/jso.26276
关键词
lung cancer; immune checkpoint; driver mutation
资金
- Fundamental Research Funds for the Central Universities [22120180607]
- National Natural Science Foundation of China [81802256]
- Shanghai Pujiang Program [15PJD034]
- Shanghai Pulmonary Hospital [FKYQ1907]
- Science and Technology Commission of Shanghai Municipality [15411968400, 14411962600]
- Shanghai Hospital Development Center [SHDC12015116]
- Shanghai Municipal Education Commission
- Shanghai Education Development Foundation [18CG19]
- Outstanding young talentproject
- Chen Guang project
This study retrospectively reviewed clinicopathological features and prognostic characteristics of 86 patients with resected pulmonary lymphoepithelioma-like carcinoma (LELC), and found that LELC has unique traits such as tendency to occur among nonsmoking young people, frequent expression of immune checkpoint, and scarcity of driver mutations. N stage and extent of resection were identified as independent predictive factors for overall survival.
Background Pulmonary lymphoepithelioma-like carcinoma (LELC) is a rare subtype of primary lung cancer. The present study aims at investigating clinicopathological features and prognostic characteristics of the resected pulmonary LELC. Methods Patients with resected pulmonary LELC were identified in our hospital from December 2008 to December 2018. Data of these patients were retrospectively reviewed, clinicopathological features and prognostic characteristics were analyzed subsequently. Results In total, 86 patients were enrolled in the study, including 39 (45.3%) males and 47 (54.7%) females. Most of the serum tumor markers were normal. Immunohistochemical staining result showed frequent differentiation traits of epithelial tissue such. Positive PD-L1 (15 of 19, 78.9%) and PD-1 (13 of 17, 76.5%) were also common, but cancer-related genetic mutation was scarce (1 of 47, 2.1%). Survival analyses demonstrated that the N stage (p = .011) and extent of resection (p = .023) were identified as independent predictive factors for overall survival. Conclusions Pulmonary LELC is a distinctive subtype of lung cancer with several exclusive traits, such as the trend to happen among nonsmoking young people, epithelial origin of tumor differentiation, frequent expression of the immune checkpoint, and scarce presence of driver mutation. In addition, pulmonary LELC was apt to get a favorable outcome, especially in cases diagnosed and treated in the early stage.
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