4.8 Article

Heat-Shrinkable Electrospun Fibrous Tape for Restoring Structure and Function of Loose Soft Tissue

期刊

ADVANCED FUNCTIONAL MATERIALS
卷 31, 期 8, 页码 -

出版社

WILEY-V C H VERLAG GMBH
DOI: 10.1002/adfm.202007440

关键词

electrospun nanofibrous membranes; extracellular matrix; soft tissues; tissue regeneration

资金

  1. National Key R&D Program of China [2019YFA0112000]
  2. National Natural Science Foundation of China General Program [51873107, 81571419]
  3. Interdisciplinary Program of Shanghai Jiao Tong University [YG2019ZDA05, ZH2018ZDA04]
  4. Five Innovations Program of International Peace Maternity and Child Health Hospital [CR2018WX01]
  5. Chinese Academy of Medical Sciences Research Unit [2019RU056]
  6. Shanghai Jiao Tong University, CAMS Innovation Fund for Medical Sciences (CIFMS) [2019-I2M-5-064]
  7. Shanghai Municipal Key Clinical Specialty
  8. Shanghai Municipal Education Commission-Gaofeng Clinical Medicine Grant Support [20171906]

向作者/读者索取更多资源

The study introduced a new approach utilizing heat-shrinkable electrospun fibrous tape (HS-EFT) to induce contraction of relaxed soft tissues, promoting fibroblast proliferation and extracellular matrix deposition for non-invasive tissue repair. The use of HS-EFT in rabbits showed promising results in reducing wound area and tissue repair, suggesting its potential in structurally and functionally reconstructing relaxed soft tissues.
Non-invasive recovery of loose soft tissue caused by trauma, organ expansion, or compression has not been solved properly. Herein, a new approach of heat-shrinkable electrospun fibrous tape (HS-EFT) is constructed via electrospinning in which the contraction of the poly(lactic-co-glycolic acid) HS-EFT causes the relaxed fascia to pull back at body temperature while the mechanical force of retraction is transformed into an external signal that regulates the behavior of fibroblasts. As it contracts more than 40% within five days, the fast proliferation of fibroblasts on the contracted fibrous membrane is observed followed by the formation of more stress fibers, consequently promoting the nuclear transfer of mechanical stimulation-sensitive co-transcriptional molecule, yes-associated protein (YAP), and eventually making new extracellular matrix (ECM) deposition, as well as tissue strengthen. Moreover, in the process of fascia defect repairing in rabbits, the loose tissue is gathered by fibrous tape which ends in a reduced wound area as well as tissue repairing. Therefore, the HS-EFT provides great inspiration for the reconstruction of relaxed soft tissue both structurally and functionally in a non-invasive way.

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