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ONCOLOGY RESEARCH (2011)
Differential Estrogen-Regulation of CXCL12 Chemokine Receptors, CXCR4 and CXCR7, Contributes to the Growth Effect of Estrogens in Breast Cancer Cells
Antoine Boudot et al.
PLOS ONE (2011)
Monomeric and dimeric CXCL12 inhibit metastasis through distinct CXCR4 interactions and signaling pathways
Luke J. Drury et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2011)
PET imaging of CXCR4 using copper-64 labeled peptide antagonist
Orit Jacobson et al.
THERANOSTICS (2011)
Recruitment of regulatory T cells is correlated with hypoxia-induced CXCR4 expression, and is associated with poor prognosis in basal-like breast cancers
Max Yan et al.
BREAST CANCER RESEARCH (2011)
Correlation between Chemokine Receptor CXCR4 Expression and Prognostic Factors in Patients with Prostate Cancer
Seok Jin Jung et al.
KOREAN JOURNAL OF UROLOGY (2011)
Severe congenital neutropenia resulting from G6PC3 deficiency with increased neutrophil CXCR4 expression and myelokathexis
David H. McDermott et al.
BLOOD (2010)
Microarray analysis of retinal endothelial tip cells identifies CXCR4 as a mediator of tip cell morphology and branching
Geraldine A. Strasser et al.
BLOOD (2010)
Live imaging of neutrophil motility in a zebrafish model of WHIM syndrome
Kevin B. Walters et al.
BLOOD (2010)
Expression pattern of stromal cell-derived factor-1 chemokine in invasive breast cancer is correlated with estrogen receptor status and patient prognosis
Takayuki Kobayashi et al.
BREAST CANCER RESEARCH AND TREATMENT (2010)
Disruption of the Blood Brain Barrier by Brain Metastases of Triple-Negative and Basal-Type Breast Cancer But Not HER2/neu-Positive Breast Cancer
Kan Yonemori et al.
CANCER (2010)
FcRγ Activation Regulates Inflammation-Associated Squamous Carcinogenesis
Pauline Andreu et al.
CANCER CELL (2010)
CXCL12 (SDF-1)/CXCR4 Pathway in Cancer
Beverly A. Teicher et al.
CLINICAL CANCER RESEARCH (2010)
CXC Chemokine Receptor 4 Is a Cell Surface Receptor for Extracellular Ubiquitin
Vikas Saini et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2010)
PET of Tumor CXCR4 Expression with 4-18F-T140
Orit Jacobson et al.
JOURNAL OF NUCLEAR MEDICINE (2010)
A CXCR4 Antagonist CTCE-9908 Inhibits Primary Tumor Growth and Metastasis of Breast Cancer (vol 155, pg 231, 2009)
Eugene H. Huang et al.
JOURNAL OF SURGICAL RESEARCH (2010)
Endothelial cells dynamically compete for the tip cell position during angiogenic sprouting
Lars Jakobsson et al.
NATURE CELL BIOLOGY (2010)
FDA Review Summary: Mozobil in Combination with Granulocyte Colony-Stimulating Factor to Mobilize Hematopoietic Stem Cells to the Peripheral Blood for Collection and Subsequent Autologous Transplantation
Michael Brave et al.
ONCOLOGY (2010)
Selective Enhancement of Donor Hematopoietic Cell Engraftment by the CXCR4 Antagonist AMD3100 in a Mouse Transplantation Model
Yubin Kang et al.
PLOS ONE (2010)
CXCR4 nanobodies (VHH-based single variable domains) potently inhibit chemotaxis and HIV-1 replication and mobilize stem cells
Sven Jahnichen et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2010)
Autocrine TGF-β and stromal cell-derived factor-1 (SDF-1) signaling drives the evolution of tumor-promoting mammary stromal myofibroblasts
Yasushi Kojima et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2010)
Structures of the CXCR4 Chemokine GPCR with Small-Molecule and Cyclic Peptide Antagonists
Beili Wu et al.
SCIENCE (2010)
Androgens Induce Functional CXCR4 through ERG Factor Expression in TMPRSS2-ERG Fusion-Positive Prostate Cancer Cells
Juan Cai et al.
TRANSLATIONAL ONCOLOGY (2010)
SDF-1/CXCR4 Contributes to the Activation of Tip Cells and Microglia in Retinal Angiogenesis
Noriyuki Unoki et al.
INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE (2010)
PET imaging of tumor CXCR4 expression with 18F-T140
Orit Jacobson et al.
JOURNAL OF NUCLEAR MEDICINE (2010)
Chemokine receptors in advanced breast cancer: differential expression in metastatic disease sites with diagnostic and therapeutic implications
N. Cabioglu et al.
ANNALS OF ONCOLOGY (2009)
The Novel CXCR4 Antagonist KRH-3955 Is an Orally Bioavailable and Extremely Potent Inhibitor of Human Immunodeficiency Virus Type 1 Infection: Comparative Studies with AMD3100
Tsutomu Murakami et al.
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY (2009)
Pharmacology of AMD3465: A small molecule antagonist of the chemokine receptor CXCR4
Veronique Bodart et al.
BIOCHEMICAL PHARMACOLOGY (2009)
64Cu-AMD3100-A novel imaging agent for targeting chemokine receptor CXCR4
Orit Jacobson et al.
BIOORGANIC & MEDICINAL CHEMISTRY (2009)
CXCR7 heterodimerizes with CXCR4 and regulates CXCL12-mediated G protein signaling
Angelique Levoye et al.
BLOOD (2009)
Positive Feedback Activation of Estrogen Receptors by the CXCL12-CXCR4 Pathway
Karine Sauve et al.
CANCER RESEARCH (2009)
Imaging chemokine receptor dimerization with firefly luciferase complementation
Kathryn E. Luker et al.
FASEB JOURNAL (2009)
Diversity in T Cell Memory: An Embarrassment of Riches
Stephen C. Jameson et al.
IMMUNITY (2009)
Hetero-oligomerization of CCR2, CCR5, and CXCR4 and the Protean Effects of Selective Antagonists
Denis Sohy et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2009)
The CXCL12 (SDF-1)/CXCR4 Axis Is Essential for the Development of Renal Vasculature
Yoshitsugu Takabatake et al.
JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY (2009)
AMD3100 Is a CXCR7 Ligand with Allosteric Agonist Properties
Irina Kalatskaya et al.
MOLECULAR PHARMACOLOGY (2009)
Effects of CXCR4 Antagonist CTCE-9908 on Prostate Tumor Growth
Stacy Porvasnik et al.
PROSTATE (2009)
A CXCR4 Antagonist CTCE-9908 Inhibits Primary Tumor Growth and Metastasis of Breast Cancer
Eugene H. Huang et al.
JOURNAL OF SURGICAL RESEARCH (2009)
Rapid mobilization of functional donor hematopoietic cells without G-CSF using AMD3100, an antagonist of the CXCR4/SDF-1 interaction
Steven M. Devine et al.
BLOOD (2008)
New insights into the role of CXCR4 in prostate cancer metastasis
Candece L. Gladson et al.
CANCER BIOLOGY & THERAPY (2008)
Synthesis and application of fluorescein- and biotin-labeled molecular probes for the chemokine receptor CXCR4
Shinya Oishi et al.
CHEMBIOCHEM (2008)
CXCL12 (SDF-1α) suppresses ongoing experimental autoimmune encephalomyelitis by selecting antigen-specific regulatory T cells
Moran Meiron et al.
JOURNAL OF EXPERIMENTAL MEDICINE (2008)
CXCR4-CCR5: A couple modulating T cell functions
Rita Lucia Contento et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2008)
17 beta-estradiol promotes breast cancer cell proliferation-inducing stromal cell-derived factor-1-mediated epidermal growth factor receptor transactivation: reversal by gefitinib pretreatment
Alessandra Pattarozzi et al.
MOLECULAR PHARMACOLOGY (2008)
Breast cancer brain metastases
Xiaoyun Cheng et al.
CANCER AND METASTASIS REVIEWS (2007)
CNS metastasis in primary breast cancer
Manish Sharma et al.
EXPERT REVIEW OF ANTICANCER THERAPY (2007)
The Novel CXCL12γ Isoform Encodes an Unstructured Cationic Domain Which Regulates Bioactivity and Interaction with Both Glycosaminoglycans and CXCR4
Cedric Laguri et al.
PLOS ONE (2007)
CXCR4 engagement promotes dendritic cell survival and maturation
Kenji Kabashima et al.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2007)
Disrupted cardiac development but normal hematopoiesis in mice deficient in the second CXCL12/SDF-1 receptor, CXCR7
Frederic Sierro et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2007)
Bicalutamide increases phospho-Akt levels through Her2 in patients with prostate cancer
Claudio Festuccia et al.
ENDOCRINE-RELATED CANCER (2007)
Distinct populations of cancer stem cells determine tumor growth and metastatic activity in human pancreatic cancer
Patrick C. Hermann et al.
CELL STEM CELL (2007)
CXCR4/CXCL12 axis promotes VEGF-mediated tumor angiogenesis through Akt signaling pathway
Zhongxing Liang et al.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2007)
Multidisciplinary management of brain Metastases
April F. Eichler et al.
ONCOLOGIST (2007)
Increased regulatory T cells correlate with CD8 T-cell impairment and poor survival in hepatocellular carcinoma patients
Junliang Fu et al.
GASTROENTEROLOGY (2007)
Tregs and rethinking cancer immunotherapy
Tyler J. Curiel
JOURNAL OF CLINICAL INVESTIGATION (2007)
Mechanisms of regulation of CXCR4/SDF-1 (CXCL12)-dependent migration and homing in multiple myeloma
Yazan Alsayed et al.
BLOOD (2007)
Regulation of CXCR4 signaling
John M. Busillo et al.
BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES (2007)
WHIM syndrome myelokathexis reproduced in the NOD/SCID mouse xenotransplant model engrafted with healthy human stem cells transduced with C-terminus-truncated CXCR4
Toshinao Kawai et al.
BLOOD (2007)
The Gα13-Rho signaling axis is required for SDF-1-induced migration through CXCR4
Wenfu Tan et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2006)
Cancer incidence before and after kidney transplantation
Claire M. Vajdic et al.
JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION (2006)
Discovery of novel, highly potent and selective β-hairpin mimetic CXCR4 inhibitors with excellent anti-HIV activity and pharmacokinetic profiles
Steven J. DeMarco et al.
BIOORGANIC & MEDICINAL CHEMISTRY (2006)
Hypoxia-inducible factor 1 and VEGF upregulate CXCR4 in glioblastoma: implications for angiogenesis and glioma cell invasion
David Zagzag et al.
LABORATORY INVESTIGATION (2006)
Stromal Derived Factor-1 (SDF-1/CXCL12) and CXCR4 in renal cell carcinoma metastasis
Judong Pan et al.
MOLECULAR CANCER (2006)
Dimerization of CXCR4 in living malignant cells: control of cell migration by a synthetic peptide that reduces homologous CXCR4 interactions
Jinhai Wang et al.
MOLECULAR CANCER THERAPEUTICS (2006)
Prevalence of FOXP3+ regulatory T cells increases during the progression of pancreatic ductal adenocarcinorna and its premalignant lesions
Nobuyoshi Hiraoka et al.
CLINICAL CANCER RESEARCH (2006)
A novel chemokine receptor for SDF-1 and I-TAC involved in cell survival, cell adhesion, and tumor development
Jennifer M. Burns et al.
JOURNAL OF EXPERIMENTAL MEDICINE (2006)
Stromal fibroblasts in cancer - A novel tumor-promoting cell type
Akira Orimo et al.
CELL CYCLE (2006)
CXCR4 physically associates with the T cell receptor to signal in T cells
Ashok Kumar et al.
IMMUNITY (2006)
Stromal cell-derived factor-1 and CXCR4 receptor interaction in tumor growth and metastasis of breast cancer
M. Z. Dewan et al.
BIOMEDICINE & PHARMACOTHERAPY (2006)
Identification and expression of novel isoforms of human stromal cell-derived factor 1
Lan Yu et al.
GENE (2006)
Development of a 111In-labeled peptide derivative targeting a chemokine receptor, CXCR4, for imaging tumors
Hirofumi Hanaoka et al.
NUCLEAR MEDICINE AND BIOLOGY (2006)
Murine B16 melanomas expressing high levels of the chemokine stromal-derived factor-1/CXCL12 induce tumor-specific T cell chemorepulsion and escape from immune control
Fabrizio Vianello et al.
JOURNAL OF IMMUNOLOGY (2006)
VEGF-induced adult neovascularization: Recruitment, retention, and role of accessory cells
M Grunewald et al.
CELL (2006)
Mice deficient in the chemokine receptor CXCR4 exhibit impaired limb innervation and myogenesis
V Ödemis et al.
MOLECULAR AND CELLULAR NEUROSCIENCE (2005)
The chemokine SDF-1/CXCL12 binds to and signals through the orphan receptor RDC1 in T lymphocytes
K Balabanian et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2005)
Fugetaxis: active movement of leukocytes away from a chemokinetic agent
F Vianello et al.
JOURNAL OF MOLECULAR MEDICINE-JMM (2005)
The p160 family coactivators regulate breast cancer cell proliferation and invasion through autocrine/paracrine activity of SDF-1α/CXCL12
H Kishimoto et al.
CARCINOGENESIS (2005)
Dendritic-cell trafficking to lymph nodes through lymphatic vessels
GJ Randolph et al.
NATURE REVIEWS IMMUNOLOGY (2005)
Stromal-derived factor-1 promotes the growth, survival, and development of human bone marrow stromal stem cells
A Kortesidis et al.
BLOOD (2005)
Stromal fibroblasts present in invasive human breast carcinomas promote tumor growth and angiogenesis through elevated SDF-1/CXCL12 secretion
A Orimo et al.
CELL (2005)
Bioluminescence resonance energy transfer reveals ligand-induced conformational changes in CXCR4 homo- and heterodimers
Y Percherancier et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2005)
Radiotherapy plus concomitant and adjuvant temozolomide for glioblastoma
R Stupp et al.
NEW ENGLAND JOURNAL OF MEDICINE (2005)
Skeletal localization and neutralization of the SDF-1(CXCL12)/CXCR4 axis blocks prostate cancer metastasis and growth in osseous sites in vivo
YX Sun et al.
JOURNAL OF BONE AND MINERAL RESEARCH (2005)
Stereoselective synthesis of [L-Arg-L/D-3-(2-naphthyl) alanine]-type (E)-alkene dipeptide isosteres and its application to the synthesis and biological evaluation of pseudopeptide analogues of the CXCR4 antagonist FC131
H Tamamura et al.
JOURNAL OF MEDICINAL CHEMISTRY (2005)
CXCR4 knockdown by small interfering RNA abrogates breast tumor growth in vivo
N Lapteva et al.
CANCER GENE THERAPY (2005)
Expression of the chemokine receptors CXCR4 and CCR7 and, disease progression in B-cell chronic lymphocytic leukemia/small lymphocytic lymphoma
IM Ghobrial et al.
MAYO CLINIC PROCEEDINGS (2004)
Safety, pharmacokinetics, and antiviral activity of AMD3100, a selective CXCR4 receptor inhibitor, in HIV-1 infection
CW Hendrix et al.
JAIDS-JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES (2004)
Dendritic cell subsets differentially regulate angiogenesis in human ovarian cancer
TJ Curiel et al.
CANCER RESEARCH (2004)
Interaction of ligand-receptor system between stromal-cell-derived factor-1 and CXC chemokine receptor 4 in human prostate cancer: a possible predictor of metastasis
H Mochizuki et al.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2004)
CXCR4 regulates growth of both primary and metastatic breast cancer
MCP Smith et al.
CANCER RESEARCH (2004)
Regulation of CXCR4 receptor dimerization by the chemokine SDF-1α and the HIV-1 coat protein gp120:: A fluorescence resonance energy transfer (FRET) study
PT Toth et al.
JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS (2004)
SDF-1 involvement in endothelial phenotype and ischemia-induced recruitment of bone marrow progenitor cells
E De Falco et al.
BLOOD (2004)
Molecular characterization of the tumor microenvironment in breast cancer
M Allinen et al.
CANCER CELL (2004)
Upregulation of CXCR4 is essential for HER2-mediated tumor metastasis
YM Li et al.
CANCER CELL (2004)
Heparan sulfate/heparin oligosaccharides protect stromal cell-derived factor-1 (SDF-1)/CXCL12 against proteolysis induced by CD26/dipeptidyl peptidase IV
R Sadir et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2004)
Role of high expression levels of CXCR4 in tumor growth, vascularization, and metastasis
M Darash-Yahana et al.
FASEB JOURNAL (2004)
Regulation of the chemokine receptor CXCR4 by hypoxia
T Schioppa et al.
JOURNAL OF EXPERIMENTAL MEDICINE (2003)
Mutations in the chemokine receptor gene CXCR4 are associated with WHIM syndrome, a combined immunodeficiency disease
PA Hernandez et al.
NATURE GENETICS (2003)
Stromal cell-derived factor 1, a novel target of estrogen receptor action, mediates the mitogenic effects of estradiol in ovarian and breast cancer cells
JM Hall et al.
MOLECULAR ENDOCRINOLOGY (2003)
A duodenally absorbable CXC chemokine receptor 4 antagonist, KRH-1636, exhibits a potent and selective anti-HIV-1 activity
K Ichiyama et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2003)
Ligand-independent dimerization of CXCR4, a principal HIV-1 coreceptor
GJ Babcock et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2003)
Synthesis of potent CXCR4 inhibitors possessing low cytotoxicity and improved biostability based on T140 derivatives
H Tamamura et al.
ORGANIC & BIOMOLECULAR CHEMISTRY (2003)
Molecular-size reduction of a potent CXCR4-chemokine antagonist using orthogonal combination of conformation- and sequence-based libraries
N Fujii et al.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2003)
Expression pattern of CXC chemokine receptor-4 is correlated with lymph node metastasis in human invasive ductal carcinoma
M Kato et al.
BREAST CANCER RESEARCH (2003)
Efficacious immunomodulatory activity of the chemokine stromal cell-derived factor 1 (SDF-1): local secretion of SDF-1 at the tumor site serves as T-cell chemoattractant and mediates T-cell-dependent antitumor responses
K Dunussi-Joannopoulos et al.
BLOOD (2002)
Chemokine receptors and stromal cells in the homing and homeostasis of chronic lymphocytic leukemia B cells
JA Burger et al.
LEUKEMIA & LYMPHOMA (2002)
Molecular physiology and pathophysiology of tight junctions in the blood-brain barrier
JD Huber et al.
TRENDS IN NEUROSCIENCES (2001)
Signal transduction by the chemokine receptor CXCR5:: Structural requirements for G protein activation analyzed by chimeric CXCR1/CXCR5 molecules
G Müller et al.
BIOLOGICAL CHEMISTRY (2001)
Involvement of chemokine receptors in breast cancer metastasis
A Müller et al.
NATURE (2001)
Induction of the chemokine stromal-derived factor-1 following DNA damage improves human stem cell function
T Ponomaryov et al.
JOURNAL OF CLINICAL INVESTIGATION (2000)
Subsecond induction of α4 integrin clustering by immobilized chemokines stimulates leukocyte tethering and rolling on endothelial vascular cell adhesion molecule 1 under flow conditions
V Grabovsky et al.
JOURNAL OF EXPERIMENTAL MEDICINE (2000)
Active movement of T cells away from a chemokine
MC Poznansky et al.
NATURE MEDICINE (2000)