期刊
ADVANCED THERAPEUTICS
卷 4, 期 2, 页码 -出版社
WILEY
DOI: 10.1002/adtp.202000165
关键词
colitis; colonic delivery; Eudragit; MCM-41; mesoporous silica; oral drug delivery
资金
- School of Pharmacy, The University of Queensland
- Mater Medical Research Institute
- National Health and Medical Research Council of Australia [GNT 1146627, GNT1143296]
The study proposes a smart drug delivery system using functionalized mesoporous silica nanoparticles and pH-responsive polymer to improve the release efficiency and reduce systemic side effects of oral glucocorticoids. Results show that this system can release drugs at colonic pH and demonstrate therapeutic efficacy in a mouse colitis model. Coated nanoparticles significantly decrease cytokine expression in the proximal colon, indicating colonic delivery effectiveness.
Oral glucocorticoids are backbones for the acute management of inflammatory bowel disease (IBD). However, the clinical effectiveness of conventional oral dosage forms of glucocorticoids is hindered by their low delivery efficiency and systemic side effects. To overcome this problem, a smart drug delivery system with high loading capacity and colonic release by coating functionalized mesoporous silica nanoparticles (MSNs) with a pH-responsive polymer Eudragit S100 is proposed. In vitro dissolution tests show that Eudragit-coated MSNs can limit the burst release of loaded prednisolone and budesonide in the gastric environment with more than 60% of the drugs released only at colonic pH (i.e., pH >= 7). In vivo therapeutic efficacy of budesonide-loaded nanoparticles is tested in a murine model of dextran sodium sulfate-induced colitis. An oral budesonide dose of 0.2 mg kg(-1)nanoparticles with Eudragit coating improves the disease activity index compared to other groups. Interestingly, both coated and uncoated nanoparticles show pathological improvements demonstrated by similar levels of histological colitis score. However, coated nanoparticles significantly decrease mRNA expression of the cytokines (Il-1 beta, Il-17, andIl-10) particularly in proximal colon, indicating colonic delivery. Overall, this study demonstrates the effectiveness of a simple method to fabricate targeted nanomedicine for the treatment of IBD.
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