期刊
CORTEX
卷 64, 期 -, 页码 271-280出版社
ELSEVIER MASSON, CORP OFF
DOI: 10.1016/j.cortex.2014.12.001
关键词
Default mode network; Working memory; Resting-state fMRI; Aging; Functional connectivity
资金
- NIH/NIA [R21 AG030770]
- NIH [T32 GM007484]
- Barbara J. Weedon Fund Fellowship at MIT
- [K01 AG040197]
We examined how variation in working memory (WM) capacity due to aging or individual differences among young adults is associated with intrinsic or resting-state anticorrelations, particularly between (1) the medial prefrontal cortex (MPFC), a component of the default-mode network (DMN) that typically decreases in activation during external, attention-demanding tasks, and (2) the dorsolateral prefrontal cortex DLPFC, a component of the fronto-parietal control network that supports executive functions and WM and typically increases in activation during attention-demanding tasks. We compared the magnitudes of MPFC-DLPFC anticorrelations between healthy younger and older participants (Experiment 1) and related the magnitudes of these anticorrelations to individual differences on two behavioral measures of VIM capacity in two independent groups of young adults (Experiments 1 and 2). Relative to younger adults, older adults exhibited reductions in WM capacity and in MPFC-DLPFC anticorrelations. Within younger adults, greater MPFC-DLPFC anticorrelation at rest correlated with greater VIM capacity. These findings show that variation in MPFC-DLPFC anticorrelations, whether related to aging or to individual differences, may reflect an intrinsic functional brain architecture supportive of WM capacity. (C) 2014 Elsevier Ltd. All rights reserved.
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