期刊
JOURNAL OF THROMBOSIS AND THROMBOLYSIS
卷 52, 期 1, 页码 42-47出版社
SPRINGER
DOI: 10.1007/s11239-020-02331-0
关键词
Serotonin; 5-hydroxytryptamin; Platelets; Cardiovascular disease
资金
- Deutsche Forschungsgemeinschaft (DFG, German Research Foundation) [413517907]
- Projekt DEAL
- IMM-PACT-Programme for Clinician Scientists, Faculty of Medicine, University of Freiburg
Cardiovascular diseases and depression are significant health burdens, with increasing evidence showing a causal relationship between them. Serotonin 5-hydroxytryptamin (5-HT) plays a role in the pathogenesis of both conditions as a neurotransmitter and peripheral hormone. Further research is needed to understand the clinical effects of 5-HT in specific tissues for targeted pharmacological therapies.
Cardiovascular diseases and depression are significant health burdens and increasing evidence suggests a causal relationship between them. The incidence of depression among patients suffering from cardiovascular disease is markedly elevated, and depression itself is an established cardiovascular risk factor. Serotonin 5-hydroxytryptamin (5-HT), a biogenic amine acting as a neurotransmitter and a peripheral hormone, is involved in the pathogenesis of both, cardiovascular disease and depression. Novel cardiovascular functions of 5-HT have recently been described and will be summarized in this review. 5-HT has a broad spectrum of functions in the cardiovascular system, yet the clinical or experimental data are partly conflicting. There is further research needed to characterize the clinical effects of 5-HT in particular tissues to enable targeted pharmacological therapies.
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